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This study was undertaken to compare and verify the antihypertensive effects of various delapril doses versus placebo on office and ambulatory blood pressure (BP). After a 2-wk placebo period, 303 patients with mild to moderate essential hypertension were randomized in a double-blind study to 8 wk of treatment with placebo, or delapril 7.5 mg twice daily, delapril 15 mg twice daily, delapril 30 mg twice daily, or delapril 30 mg once daily. BP changes versus baseline and rates of normalized office systolic blood pressure (SBP)or = 20 mm Hg and office DBPor = 10 mm Hg, were calculated. In the intention-to-treat population (n=296), office SBP and DBP reductions were more notable with 30 mg twice daily (15.6/11.5 mm Hg) and 15 mg twice daily (14.8/12.5 mm Hg) than with other delapril regimens (30 mg once daily: 11.8/10.5 mm Hg; 7.5 mg twic!
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To determine the accuracy of the Microlife WatchBP O3 blood pressure measuring device tested according to the requirements of the International Protocol of the European Society of Hypertension. The WatchBP O3 is designed to provide clinic, ambulatory, and self blood pressure (BP) measurements. Device evaluation was performed in 33 participants with a mean +/- standard deviation age of 56.1+/-20.7 years (range 30-95 years). Their systolic BP (SBP) was 144.7+/-24.1 mmHg (range 90-180 mmHg), diastolic BP (DBP) was 86.8+/-18.3 mmHg (range 50-120 mmHg), and arm circumference was 28.1+/-2.9 cm (range 22.0-34.0 cm). Blood pressure measurements were performed in the sitting position. The WatchBP O3 passed all three phases of the European Society of Hypertension protocol for SBP and DBP. Mean blood pressure differences for the WatchBP O3 (device observer) were -1.7+/-6.9 mmHg for SBP and -1.1+/-4.3 mmHg for DBP. In conclusion, these results indicate that the Microlife WatchBP O3 moni!
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